反应详情

A solution of 2-amino-pyridine (2 g, 21 mmol) and ethyl bromopyruvate (4.14 g, 21 mmol) in ethanol (31 mL) was stirred under reflux for 24 h. The solvent was evaporated, and the residue was dissolved in a minimum volume of water. The solution was neutralized (pH=8) with saturated NaHCO3. The aqueous layer was extracted with AcOEt and the organic layer was washed with saturated NaCl. The solvent was removed under pressure to afford 2.51 g of ethyl imidazo[1,2-a]pyridine-2-carboxylate (Yield: 62%) as an orange oil which can be used without further purification.

1. temperatureunder reflux for 24 h
2. customThe solvent was evaporated
3. dissolutionthe residue was dissolved in a minimum volume of water
4. extractionThe aqueous layer was extracted with AcOEt
5. washthe organic layer was washed with saturated NaCl
6. customThe solvent was removed under pressure