HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → HCID 10495408, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole | HCID 10758603 | — |
| Product | HCID 10495408 | HCID 10495408 | 87% |
Reaction Steps
By the method used in Example 1, Part D, 1.25 g (3.8 mmol) of 1-([1,1'-biphenyl]-3-ylmethyl)-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 15.2 mL of 1M BBr3 /CH2 Cl2 to give 1.03 g (87% yield) of crude 1-([1,1'-biphenyl]-3-ylmethyl)-4-hydroxy-2-methyl-1H-indole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05733923 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-5df3c79084144f99bcdc789e25be2a1e |
| Source note | uspto-grants-1998_03 |