5-phenyl-2-(4-trimethylsilanyl-but-3-ynyl)-2H-pyrazole → 5-phenyl-1-(4-trimethylsilanyl-but-3-ynyl)-1H-pyrazole

HRID 334622Notes

Reaction equation

HRID 334622 reaction equation
[C:1]1([C:7]2[CH:11]=[CH:10][NH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C2C=CN([CH2:23][CH2:24][C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])N=2)C=CC=CC=1>>[C:1]1([C:7]2[N:8]([CH2:23][CH2:24][C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[N:9]=[CH:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 665980525-phenyl-2-(4-trimethylsilanyl-but-3-ynyl)-2H-pyrazoleHCID 178420101HCID 178420101, compound

Product 1

HCID 665984445-phenyl-1-(4-trimethylsilanyl-but-3-ynyl)-1H-pyrazoleYield 81%

Procedure

The title compounds were prepared in accordance with the general method of Example 108(A), from 3-phenyl-1H-pyrazole (200 mg, 1.39 mmol) to yield 300 mg (1.12 mmol, 81%) of 5-phenyl-1-(4-trimethylsilanyl-but-3-ynyl)-1H-pyrazole and 5-phenyl-2-(4-trimethylsilanyl-but-3-ynyl)-2H-pyrazole.

Sources & evidence

ORD record
ord-4de56347dd774914b1f75964cc26d5ac
Source dataset
uspto-grants-2014_11
Patent number
US08883826B2

Reaction notes

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