HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-nitrobenzaldehyde → 6-fluoro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-nitrobenzaldehyde | HCID 76226 | — |
| Reactant | (4-Aminobut-1-yn-1-yl)trimethylsilane | HCID 19703099 | — |
| Product | 6-fluoro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole | HCID 66597905 | 100% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 149(A), from 4-fluoro-2-nitro-benzaldehyde (180 mg, 1.06 mmol) and 4-trimethylsilanyl-but-3-ynylamine (200 mg, 1.40 mmol). The crude product was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 6-fluoro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole (310 mg, 1.06 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883826B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f6ea74b351a4457d838c70304d1e858d |
| Source note | uspto-grants-2014_11 |