HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Iodopyridine → 4-Pyridin-2-yl-1-quinoxalin-2-yl-but-3-yn-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Iodopyridine | HCID 221126 | — |
| Reactant | 1-Quinoxalin-2-yl-but-3-yn-1-ol | HCID 86630247 | — |
| Product | 4-Pyridin-2-yl-1-quinoxalin-2-yl-but-3-yn-1-ol | HCID 66597902 | 62.9% |
Reaction Steps
The title compound was prepared in accordance with the general method of Example 1, from 2-iodo-pyridine (72 mg, 0.35 mmol) and 1-quinoxalin-2-yl-but-3-yn-1-ol (70 mg, 0.35 mmol). Reaction time: 14 hours. The crude residue was purified by flash chromatography (cyclohexane/AcOEt 3:2 to DCM/MeOH 9:1) to yield 60 mg (0.22 mmol, 62%) of 4-pyridin-2-yl-1-quinoxalin-2-yl-but-3-yn-1-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883826B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-68e2af3aaf0340d68a8eb433adcaaf0a |
| Source note | uspto-grants-2014_11 |