HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4-Oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbaldehyde | HCID 59796775 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-Oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbonitrile | HCID 24758390 | — |
Reaction Steps
A solution of 4-oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbaldehyde (v) in isopropanol (“iPrOH”) is treated with ammonia gas at room temperature. After 90 min, the reaction is treated with MnO2 and stirred for an additional 16 h. The reaction is filtered and evaporated onto celite. Chromatography on silica gel affords 4-oxo-6-piperidin-1-yl-4,5-dihydro-furo[2,3-c]quinoline-2-carbonitrile. IV. Results
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429603B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-935217ab03d94313ab188f15be559684 |
| Source note | uspto-grants-2008_09 |