HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 334778Generated: October 27, 2026
Potassium Carbonate → 1-methyl-3-(5-(pyridin-2-yl)pent-4-ynyl)-1H-benzo[d]imidazol-2(3H)-one
https://huagongshe.com/reaction/334778
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one | HCID 590540 | — |
| Reactant | 2-(5-Chloropent-1-ynyl)pyridine | HCID 66598557 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-methyl-3-(5-(pyridin-2-yl)pent-4-ynyl)-1H-benzo[d]imidazol-2(3H)-one | HCID 66598144 | 45.8% |
Reaction Steps
2-(5-chloropent-1-ynyl)pyridine (59 mg, 0.33 mmol), 1-methyl-1H-benzo[d]imidazol-2(3H)-one (44 mg, 0.3 mmol) and K2CO3 (70 mg, 0.51 mmol) were poured into DMF (0.45 mL) and the resulting mixture was heated at 50° C. overnight. The mixture was purified over silicagel chromatography (prepacked 25 g silicagel column, DCM 100% as eluent) to afford 40 mg of 1-methyl-3-(5-(pyridin-2-yl)pent-4-ynyl)-1H-benzo[d]imidazol-2(3H)-one as a yellow oil (Yield: 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08883826B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-83432cb15cee4409a8fe924eae9ae077 |
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| Source note | uspto-grants-2014_11 |
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