o-Chlorothiophenol → 3-(2-Chlorophenylthio)-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride

HRID 335083Notes

Reaction equation

HRID 335083 reaction equation
Br[C:2]1[C:3]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[SH:22]>>[ClH:15].[Cl:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[S:22][C:2]1[C:3]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 80599o-ChlorothiophenolHCID 613756483-bromo-N-(4-methylthiazol-2-yl)pyridin-2-amine

Product 1

HCID 247658333-(2-Chlorophenylthio)-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride

Procedure

Prepared according to the method of Example 13, with 3-bromo-N-(4-methylthiazol-2-yl)pyridin-2-amine and 2-chlorobenzenethiol. 1H NMR (d6-DMSO) δ 8.45 (m, 1H), 7.80 (bs, 1H), 7.57 (m, 1H), 7.27 (m, 2H), 7.07 (m, 1H), 6.84 (m, 1H), 6.62 (m, 1H), 2.21 (s, 3H); Mass spectrum (esi) m/z=334.2 (100)(M+H—HCl).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-73cff004e3234d4cb2c3ded5fa7f9a0f
Source dataset
uspto-grants-2014_11
Patent number
US08883828B2

Reaction notes

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