Thiophenol → N-(3-(2-chlorophenylthio)-5-(phenylthio)pyridin-2-yl)-4-methylthiazol-2-amine hydrochloride

HRID 335099Notes

Reaction equation

HRID 335099 reaction equation
Br[C:2]1[CH:3]=[C:4]([S:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:6][CH:7]=1.[C:23]1([SH:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[ClH:22].[Cl:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[S:15][C:4]1[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH3:14])[N:13]=2)=[N:6][CH:7]=[C:2]([S:29][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 24764526N-(5-bromo-3-(2-chlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine

Product 1

HCID 24764614N-(3-(2-chlorophenylthio)-5-(phenylthio)pyridin-2-yl)-4-methylthiazol-2-amine hydrochloride

Procedure

Prepared according to the method of Example 13 from N-(5-bromo-3-(2-chlorophenylthio)pyridin-2-yl)-4-methylthiazol-2-amine (prepared according to Example 47) and benzenethiol. 1H NMR (d6-DMSO) δ 8.36 (bs, 1H), 7.57 (dd, 1H), 7.40-7.15 (m, 100H), 6.54 (s, 1H), 2.20 (s, 3H); Mass spectrum (esi) m/z=442.2 (M+H—HCl).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0408a8ef2f3e4be8b9504d550d95ffd1
Source dataset
uspto-grants-2014_11
Patent number
US08883828B2

Reaction notes

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