HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 335160Generated: October 30, 2026
tert-Butyl 4-formylpiperidine-1-carboxylate → tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate
https://huagongshe.com/reaction/335160
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl 4-formylpiperidine-1-carboxylate | HCID 1514430 | — |
| Reactant | HCID 178418573 | HCID 178418573 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | tert-Butyl 4-(1-hydroxyethyl)piperidine-1-carboxylate | HCID 21989903 | 90.2% |
Reaction Steps
Placed tert-butyl 4-formylpiperidine-1-carboxylate (2.00 g, 9.38 mmol) in THF (40 mL) and cooled to −78° C. Slowly added methylmagnesium bromide (3.44 mL, 10.3 mmol) stirred for 1 hour. Slowly added saturated ammonium chloride and extracted with CH2Cl2. Concentrated and redisolved in 5% MeOH in CH2Cl2. Added ether and filtered off solids. Concentrate filtrate to give the title compound (1.94 g, 90.2% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08883828B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-f74a501c8d334299b665840262278a57 |
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| Source note | uspto-grants-2014_11 |
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