Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 335196생성일: 2026년 10월 25일
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 3-(2-(5-bromo-3-phenoxypyridin-2-ylamino)thiazol-4-yl)-N-(2-oxopropyl)propanamide
https://huagongshe.com/reaction/335196
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| 반응물 | 2-Propanone, 1-amino-, hydrochloride | HCID 3084025 | — |
| 반응물 | 3-(2-(5-Bromo-3-phenoxypyridin-2-ylamino)thiazol-4-yl)propanoic acid | HCID 57742671 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-(2-(5-bromo-3-phenoxypyridin-2-ylamino)thiazol-4-yl)-N-(2-oxopropyl)propanamide | HCID 86631511 | — |
반응 단계
A mixture of 3-(2-(5-bromo-3-phenoxypyridin-2-ylamino)thiazol-4-yl)propanoic acid (0.800 g, 1.90 mmol), HOBT-H2O (0.437 g, 2.86 mmol), DIEA (1.36 mL, 7.80 mmol), EDCI (0.547 g, 2.86 mmol), and 1-aminopropan-2-one hydrochloride (0.834 g, 7.61 mmol) in 50 mL THF was stirred at 50° C. for 2 days. The mixture was concentrated and diluted with CH2Cl2 and washed with water, dried over sodium sulfate and concentrated to a residue that was carried on to the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08883828B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
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| ORD ID | ord-fa236ce5a76348cc90fe3f84b196a196 |
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| 출처 메모 | uspto-grants-2014_11 |
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