Thiophenol → HCID 86631512, compound

HRID 335200Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][Cl:15])[N:13]=2)=[N:6][CH:7]=1.[C:23]1([SH:29])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[ClH:15].[Br:1][C:2]1[CH:3]=[C:4]([O:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:5]([NH:8][C:9]2[S:10][CH:11]=[C:12]([CH2:14][S:29][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[N:13]=2)=[N:6][CH:7]=1

Participants

Reactant 2

HCID 7969Thiophenol

HCID 57742594HCID 57742594, compound

Product 1

HCID 86631512HCID 86631512, compound

Procedure

Prepared according to the method of Example 345 using 5-bromo-N-(4-(chloromethyl)thiazol-2-yl)-3-phenoxypyridin-2-amine and benzenethiol. 1H NMR (CDCl3) δ 4.13 (s, 2H), 6.48 (s, 1H), 7.19 (d, J=8.0 Hz, 2H), 7.26-7.32 (m, 5H), 7.38 (d, J=7.0 Hz, 2H), 7.44 (t, J=7.6 Hz, 2H), 8.12 (d, J=1.6 Hz, 1H), 12.71 (s, 1H).

Workup

customPrepared

Sources & evidence

ORD record: ord-6180689eed0445e490fa730a815ec13b
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883828B2

Reaction notes

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