Water → HCID 86631516, compound

Participants

Reaction Steps

To a mixture of methyl 3-(2-(5-bromo-3-(phenylthio)pyridin-2-ylamino)thiazol-4-yl)propanoate (1.40 g, 3.11 mmol) in 50 mL THF was added 25 mL water followed by sodium hydroxide (0.249 g, 6.22 mmol) and the mixture was stirred overnight. The mixture was concentrated to dryness, water added and acidified with NH4C1. The mixture was then extracted with THF. The organics were dried over Na2SO4 and concentrated to give the title compound (1.38 g, 102% yield) that was used as the crude material.

Provenance & Evidence