反应详情

A solution of 2-(trifluoromethyl)benzenethiol (0.185 mL, 1.40 mmol) in wet acetonitrile (1:5 water/acetonitrile) was added Iodine (0.178 g, 0.702 mmol) and allowed to stir over night at room temperature. The reaction was concentrated, then diluted with EtOAc and quenched with aqueous sodium thiosulfate, extracted and dried organic with brine, Na2SO4, filtered and concentrated to afford the title compound (219 mg, 44% yield) as a colorless oil.

1. concentrationThe reaction was concentrated
2. additiondiluted with EtOAc
3. customquenched with aqueous sodium thiosulfate
4. extractionextracted and dried organic with brine, Na2SO4
5. filtrationfiltered
6. concentrationconcentrated