反应详情

A mixture comprising 7-bromo-N-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (Intermediate 3A) 100 mg, 0.199 mmol), 6-chloropyridin-3-ylboronic acid (31.3 mg, 0.199 mmol) and cesium carbonate (259 mg, 0.795 mmol) in DME (631 μL)/water (31.5 μL) was purged with nitrogen and treated with PdCl2(dppf).CH2Cl2 adduct (8.11 mg, 9.93 μmol) The resulting mixture was heated using microwave radiation at 100° C. for 15 mins. The water was removed by pipette and the reaction mixture was diluted with MeOH. Purification of the mixture by chromatography on silica eluting with 0-20% 2M NH3 in MeOH/DCM afforded the title compound;

1. customat 100° C.
2. customfor 15 mins
3. customThe water was removed by pipette
4. additionthe reaction mixture was diluted with MeOH
5. customPurification of the mixture by chromatography on silica eluting with 0-20% 2M NH3 in MeOH/DCM