Pyrazolo[1,5-a]pyridine-3-carbonyl chloride → N-(2-Bromo-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:22]=[CH:23][C:24]=1[Br:25])[C:5]([NH:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1)=[O:6].[N:26]1[N:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]2=[C:28]([C:35](Cl)=[O:36])[CH:27]=1>>[Br:25][C:24]1[CH:23]=[CH:22][C:4]([C:5](=[O:6])[NH:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)=[CH:3][C:2]=1[NH:1][C:35]([C:28]1[CH:27]=[N:26][N:30]2[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=12)=[O:36]Participants
3
Procedure
The title compound was prepared from 3-amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide (Ex 5.1, step 1) and pyrazolo[1,5-a]pyridine-3-carbonyl chloride (commercially available) analogously to Example 5.1;
Sources & evidence
- ORD record
- ord-719e14b983ea4ed7af37cdbd297d413d
- Source dataset
- uspto-grants-2014_11
- Patent number
- US08883819B2
Reaction notes
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