(1R,2R)-2-Aminocyclohexanol → HCID 71283353, compound

HRID 335294Notes

Reaction equation

HRID 335294 reaction equation
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[OH:8].[CH3:9][C:10]1([CH3:49])[CH2:14][CH2:13][CH2:12][N:11]1[CH2:15][CH2:16][NH:17][C:18]([C:20]1[CH:21]=[CH:22][C:23]([F:48])=[C:24]([NH:26][C:27]([C:29]2[N:33]3[CH:34]=[CH:35][C:36]([C:38]4[CH:46]=[CH:45][C:41]([C:42](O)=[O:43])=[C:40]([F:47])[CH:39]=4)=[CH:37][C:32]3=[N:31][CH:30]=2)=[O:28])[CH:25]=1)=[O:19]>>[CH3:9][C:10]1([CH3:49])[CH2:14][CH2:13][CH2:12][N:11]1[CH2:15][CH2:16][NH:17][C:18]([C:20]1[CH:21]=[CH:22][C:23]([F:48])=[C:24]([NH:26][C:27]([C:29]2[N:33]3[CH:34]=[CH:35][C:36]([C:38]4[CH:46]=[CH:45][C:41]([C:42](=[O:43])[NH:1][C@@H:2]5[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]5[OH:8])=[C:40]([F:47])[CH:39]=4)=[CH:37][C:32]3=[N:31][CH:30]=2)=[O:28])[CH:25]=1)=[O:19]

Participants

3

Reactant 2

HCID 735777(1R,2R)-2-AminocyclohexanolHCID 71283788HCID 71283788, compound

Product 1

HCID 71283353HCID 71283353, compound

Procedure

The title compound was prepared from (1R,2R)-2-aminocyclohexanol and 4-(3-(5-(2-(2,2-dimethylpyrrolidin-1-yl)ethylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic acid (step 3) analogously to Example 7.3 step 2;

Sources & evidence

ORD record
ord-6db647d788d34a3e8441bd5af6b82cd3
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Reaction notes

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