돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 335297생성일: 2026년 10월 25일

Sodium Hydroxide → 4-(3-(5-(3,4-Difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic Acid

https://huagongshe.com/reaction/335297

반응식

참여 물질

역할이름HCID투입량
반응물Sodium HydroxideHCID 14798—
반응물Methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoateHCID 71283111—
용매MethanolHCID 887—
생성물4-(3-(5-(3,4-Difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoic AcidHCID 71283527—

반응 단계

A solution of methyl 4-(3-(5-(3,4-difluorobenzylcarbamoyl)-2-fluorophenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)-2-fluorobenzoate (Example 7.1, step 1) (497 mg, 0.862 mmol) and 2M NaOH (4311 μL, 8.62 mmol) in MeOH (2874 μL) was stirred at RT overnight. The solvent was removed in vacuo and the residue was acidified with 2M HCl to pH 2 and extracted with DCM. The organic extracts were dried over MgSO4, filtered and concentrated in vacuo to afford the title compound;

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08883819B2
출처 데이터셋uspto-grants-2014_11
ORD IDord-fc95246d06424243be4e6765af724f0c
출처 메모uspto-grants-2014_11