HRID335298

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2782818

[3-Fluoro-4-(methoxycarbonyl)phenyl]boronic acid

C8H8BFO4

结构：C[C@@H]1CCC[C@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(Br)ccn23)c1

HCID71283219

未命名化合物

2 次

PRODUCTS

生成物

结构：C[C@@H]1CCC[C@H](C)N1CCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(-c4ccc(C(=O)O)c(F)c4)ccn23)c1

HCID71283338

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 7-bromo-N-(5-(2-(2,6-cis-dimethylpiperidin-1-yl)ethylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (Intermediate 4C) and 3-fluoro-4-(methoxycarbonyl)phenylboronic acid analogously to Example 1.20;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-517ae9f117664e2baf116881e32b171e
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08883819B2
来源说明: uspto-grants-2014_11

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([NH:13][C:14]3[CH:19]=[C:18]([C:20](=[O:32])[NH:21][CH2:22][CH2:23][N:24]4[C@H:29]([CH3:30])[CH2:28][CH2:27][CH2:26][C@@H:25]4[CH3:31])[CH:17]=[CH:16][C:15]=3[F:33])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.[F:34][C:35]1[CH:36]=[C:37](B(O)O)[CH:38]=[CH:39][C:40]=1[C:41]([O:43]C)=[O:42]>>[CH3:30][C@H:29]1[CH2:28][CH2:27][CH2:26][C@@H:25]([CH3:31])[N:24]1[CH2:23][CH2:22][NH:21][C:20]([C:18]1[CH:17]=[CH:16][C:15]([F:33])=[C:14]([NH:13][C:11]([C:8]2[N:5]3[CH:6]=[CH:7][C:2]([C:37]4[CH:38]=[CH:39][C:40]([C:41]([OH:43])=[O:42])=[C:35]([F:34])[CH:36]=4)=[CH:3][C:4]3=[N:10][CH:9]=2)=[O:12])[CH:19]=1)=[O:32]