HRID335300

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2782818

[3-Fluoro-4-(methoxycarbonyl)phenyl]boronic acid

C8H8BFO4

结构：CN1CCN(c2ccccc2CNC(=O)c2ccc(F)c(NC(=O)c3cnc4cc(Br)ccn34)c2)CC1

HCID71283095

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1ccc(-c2ccn3c(C(=O)Nc4cc(C(=O)NCc5ccccc5N5CCN(C)CC5)ccc4F)cnc3c2)cc1F

HCID71283699

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from 7-Bromo-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide (Example 1.1 step 1) and 3-fluoro-4-(methoxycarbonyl)phenylboronic acid analogously to Example 1.1 step 2;

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c73a309807b4fdab09b0932293be74f
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08883819B2
来源说明: uspto-grants-2014_11

反应 SMILES

Br[C:2]1[CH:7]=[CH:6][N:5]2[C:8]([C:11]([NH:13][C:14]3[CH:19]=[C:18]([C:20](=[O:36])[NH:21][CH2:22][C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[N:29]4[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]4)[CH:17]=[CH:16][C:15]=3[F:37])=[O:12])=[CH:9][N:10]=[C:4]2[CH:3]=1.[F:38][C:39]1[CH:40]=[C:41](B(O)O)[CH:42]=[CH:43][C:44]=1[C:45]([O:47][CH3:48])=[O:46]>>[F:38][C:39]1[CH:40]=[C:41]([C:2]2[CH:7]=[CH:6][N:5]3[C:8]([C:11](=[O:12])[NH:13][C:14]4[CH:19]=[C:18]([C:20](=[O:36])[NH:21][CH2:22][C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=5[N:29]5[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]5)[CH:17]=[CH:16][C:15]=4[F:37])=[CH:9][N:10]=[C:4]3[CH:3]=2)[CH:42]=[CH:43][C:44]=1[C:45]([O:47][CH3:48])=[O:46]