2-Fluoroethylamine → 7-(3-Fluoro-4-(2-fluoroethylcarbamoyl)phenyl)-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	2-Fluoroethylamine	HCID 9996	—
Reactant	Methyl 2-fluoro-4-(3-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)benzoate	HCID 71283699	—
Product	7-(3-Fluoro-4-(2-fluoroethylcarbamoyl)phenyl)-N-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenyl)imidazo[1,2-a]pyridine-3-carboxamide	HCID 71506428	—

Reaction Steps

The title compound was prepared from methyl 2-fluoro-4-(3-(2-fluoro-5-(2-(4-methylpiperazin-1-yl)benzylcarbamoyl)phenylcarbamoyl)imidazo[1,2-a]pyridin-7-yl)benzoate (step) and 2-fluoroethanamine analogously Example 8.1 steps 1 and 2; LC-MS: Rt 0.74 mins; MS m/z 670/671 {M+H}+; Method 2minLC_v003

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08883819B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-d51a69d676264d63ba14d5fb83c6694a
Source note	uspto-grants-2014_11