反应详情

温度

110 °C

6-Bromopyrazolo[1,5-a]pyridine-3-carboxylic acid (7.71 g, 32.0 mmol) in toluene (80 ml) was treated with thionyl chloride (18.67 ml, 256 mmol) and was heated to 110° C. for 6 hr. The solvent was removed in vacuo and the residue was treated with pyridine (80 ml), methyl 5-amino-6-methylnicotinate (4.25 g, 25.6 mmol) and oven dried molecular sieves. The reaction mixture was stirred at RT overnight and then treated with MeOH (250 ml). The resulting suspension was removed by filtration. The filtrate was triturated with methanol and the solid produced was isolated to afford the title compound;

1. customThe solvent was removed in vacuo
2. customdried molecular sieves
3. additiontreated with MeOH (250 ml)
4. customThe resulting suspension was removed by filtration
5. customThe filtrate was triturated with methanol
6. customthe solid produced
7. customwas isolated