HRID335320

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OCCNC(=O)c1ccc(F)c(NC(=O)c2cnc3cc(Br)ccn23)c1

HCID71283486

未命名化合物

结构：Cc1cc(F)c(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1N

HCID86695683

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(F)c(C(=O)NCc2ccccc2N2CCN(C)CC2)cc1NC(=O)c1cnc2cc(Br)ccn12

HCID71283104

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from 5-amino-2-fluoro-4-methyl-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide (step 3) analogously to 7-bromo-N-(5-(2-tert-butoxyethylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide (Intermediate 2a step 2);

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c978185c3bbd40c3a9f631ea5194d078
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08883819B2
来源说明: uspto-grants-2014_11

反应 SMILES

[NH2:1][C:2]1[C:3]([CH3:26])=[CH:4][C:5]([F:25])=[C:6]([CH:24]=1)[C:7]([NH:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[N:17]1[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]1)=[O:8].[Br:27][C:28]1[CH:33]=[CH:32][N:31]2[C:34]([C:37](NC3C=C(C(=O)NCCOC(C)(C)C)C=CC=3F)=[O:38])=[CH:35][N:36]=[C:30]2[CH:29]=1>>[Br:27][C:28]1[CH:33]=[CH:32][N:31]2[C:34]([C:37]([NH:1][C:2]3[CH:24]=[C:6]([C:7](=[O:8])[NH:9][CH2:10][C:11]4[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=4[N:17]4[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]4)[C:5]([F:25])=[CH:4][C:3]=3[CH3:26])=[O:38])=[CH:35][N:36]=[C:30]2[CH:29]=1