6-Bromopyrazolo(1,5-a)pyridine-3-carboxylic acid → 6-Bromo-N-(5-(2-tert-butoxyethylcarbamoyl)-2-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

HRID 335321Notes

Reaction equation

HRID 335321 reaction equation
BrC1C=CN2C(C([NH:13][C:14]3[CH:19]=[C:18]([C:20](=[O:29])[NH:21][CH2:22][CH2:23][O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[CH:17]=[CH:16][C:15]=3[F:30])=O)=CN=C2C=1.[Br:31][C:32]1[CH:33]=[CH:34][C:35]2[N:36]([N:38]=[CH:39][C:40]=2[C:41]([OH:43])=O)[CH:37]=1>>[Br:31][C:32]1[CH:33]=[CH:34][C:35]2[N:36]([N:38]=[CH:39][C:40]=2[C:41]([NH:13][C:14]2[CH:19]=[C:18]([C:20](=[O:29])[NH:21][CH2:22][CH2:23][O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH:17]=[CH:16][C:15]=2[F:30])=[O:43])[CH:37]=1

Participants

3

Reactant 2

HCID 573723196-Bromopyrazolo(1,5-a)pyridine-3-carboxylic acidHCID 712834867-Bromo-N-(5-(2-tert-butoxyethylcarbamoyl)-2-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxamide

Product 1

HCID 712833356-Bromo-N-(5-(2-tert-butoxyethylcarbamoyl)-2-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide

Procedure

The title compound was prepared analogously to Intermediate 2A by replacing 6-bromoimidazo[1,2-a]pyridine-3-carboxylic acid (step 2) with 6-bromopyrazolo[1,5-a]pyridine-3-carboxylic acid (commercially available);

Sources & evidence

ORD record
ord-a414922f7ad54a96a41b875faa5a9884
Source dataset
uspto-grants-2014_11
Patent number
US08883819B2

Reaction notes

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