反应详情

Chlorosulfonylisocyanate (5.17 ml, 59.4 mmol) in DCM (12 ml) was stirred at 25° C. and treated dropwise with (E)-hex-3-ene (7.39 ml, 59.4 mmol) in DCM (6 ml). The mixture was stirred at RT for 72 hrs. The reaction mixture was heated over 6 hrs at 40° C., before being poured onto ice. The mixture was extracted with DCM (3×100 ml) and the combined organics were washed with water (×1), dried MgSO4 and evaporated to dryness to afford the title compound;

1. temperatureThe reaction mixture was heated over 6 hrs at 40° C.
2. additionbefore being poured onto ice
3. extractionThe mixture was extracted with DCM (3×100 ml)
4. washthe combined organics were washed with water (×1), dried MgSO4
5. customevaporated to dryness