HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 335380Generated: October 25, 2026
Water → N-(Pyrazinylcarbonyl)-L-phenylalanine
https://huagongshe.com/reaction/335380
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 73058-37-4 | HCID 12580944 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(Pyrazinylcarbonyl)-L-phenylalanine | HCID 15042559 | — |
Reaction Steps
Dissolve (S)-Methyl 3-phenyl-2-(pyrazine-2-carboxamido)propanoate (57.65 g) in 572 ml of acetonitrile and add 11.7 ml water and 84 ml of triethylamine. Cool the reaction mixture to 0° C. on ice bath and add 175.0 g of LiBr in several portions at vigorous stirring. After 10 minutes of stirring, increase the temperature to ambient temperature. (NB. A HPLC sample showed 99.97% conversion with 98.78% content of the desired product).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08884009B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-f6dcf495aa434736b4964ee0c80be9a9 |
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| Source note | uspto-grants-2014_11 |
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