Sodium Hydroxide → HCID 56942713, compound

HRID 335399Notes

Reaction equation

[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12]1[C:13](=[O:24])[N:14]([CH3:23])[N:15]=[C:16]([CH3:22])[C:17]=1S(C)(=O)=O)[CH3:2].[OH-:25].[Na+]>O>[CH2:2]([O:25][C:17]1[C:16]([CH3:22])=[N:15][N:14]([CH3:23])[C:13](=[O:24])[C:12]=1[C:4]1[C:3]([CH2:1][CH3:2])=[CH:8][C:7]([CH3:9])=[CH:6][C:5]=1[CH2:10][CH3:11])[CH2:1][CH2:3][CH3:4]

Participants

Conditions

Temperature: 120 °C

Procedure

To a test tube (outside diameter: 21 mm φ×overall length: 160 mm), 4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-5-methylsulfonyl-2,3-dihydropyridazin-3-one ((2-34)-(1)-39) (0.21 g), 1-butanol1 (4 ml), water (0.1 ml), and sodium hydroxide (0.20 g) were added under a nitrogen atmosphere at room temperature, and stirred at 120° C. for 8 hours. Then, to the reaction mixture was added water at room temperature, and extracted with tert-butyl methyl ether. The resulting organic layer was concentrated under reduced pressure to give 0.74 g of 5-(n-butoxy)-4-(2,6-diethyl-4-methylphenyl)-2,6-dimethyl-2,3-dihydro-3-pyridazinone ((1-5)-(1)-39).

Workup

extractionextracted with tert-butyl methyl ether
concentrationThe resulting organic layer was concentrated under reduced pressure

Sources & evidence

ORD record: ord-f6f379b6961144ab82db1de896c57e8d
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08884010B2

Reaction notes

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