HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 335455Generated: October 28, 2026
Thionyl Chloride → 2-[5-(4-Chlorophenyl)-2-ethylphenyl]-2-oxoacetyl chloride
https://huagongshe.com/reaction/335455
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-[5-(4-Chlorophenyl)-2-ethylphenyl]-2-oxoacetic acid | HCID 66691555 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-[5-(4-Chlorophenyl)-2-ethylphenyl]-2-oxoacetyl chloride | HCID 56942557 | 87.2% |
Reaction Steps
To a 20 ml volume three-necked flask, 2-[5-(4-chlorophenyl)-2-ethylphenyl]-2-oxoacetic acid (8-c) (1.01 g), toluene (3.5 ml), dimethylformamide (3 drops), and thionyl chloride (624 mg) were added under a nitrogen atmosphere, and stirred at 50° C. for 3 hours. The mixture was concentrated under reduced pressure, and azeotropic-distilled with toluene 3 times to give 937 mg of 2-[5-(4-chlorophenyl)-2-ethylphenyl]-2-oxoacetyl chloride (6-c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08884010B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-9db1dcce6a5c48eebd928d188d0bcfde |
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| Source note | uspto-grants-2014_11 |
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