反应详情

To a 100 mL volume three-necked flask, 10.0 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 38 ml of methanol and 6.93 g of 37 wt % formalin aqueous solution were added and the mixture was stirred at room temperature for 5 hours. Methanol was added to the reaction mixture and cooled on ice-bath. The precipitated crystals were collected by filtration, washed with cool methanol, and dried under reduced pressure to give 1.22 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-methylidenehydrazine ((40-a)-(14)-1).

1. temperaturecooled on ice-bath
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed with cool methanol
4. customdried under reduced pressure