Formaldehyde → HCID 66691343, compound

HRID 335484Notes

Reaction equation

HRID 335484 reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:18])[C:13]([N:15]([CH3:17])[NH2:16])=[O:14])[CH3:2].[CH3:19]O.C=O>O>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:18])[C:13]([N:15]([CH3:17])[N:16]=[CH2:19])=[O:14])[CH3:2]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 887MethanolHCID 569428781-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-1-methylhydrazine

Product 1

HCID 66691343HCID 66691343, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a test tube (outside diameter 21 mmφ×overall length 160 mm), 100 mg of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-1-methylhydrazine ((12-2)-(11)-39), 380 mg of methanol and 130 μl of 37 wt % formalin aqueous solution were added and the mixture was stirred at room temperature for 2.5 hours. Water was added to the reaction mixture and the resultant was extracted with chloroform three times. The organic layers were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 97 mg of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-1-methyl-2-methylidenehydrazine ((40-b)-(15)-1).

Workup

  1. extractionthe resultant was extracted with chloroform three times
  2. dry with materialdried over anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-456e5a5c48ec4f82b8461854cb2fa6b4
Source dataset
uspto-grants-2014_11
Patent number
US08884010B2

Reaction notes

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