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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 335509Generated: October 31, 2026

2-Chloropyrimidine → 2-(Tributylstannyl)pyrimidine

https://huagongshe.com/reaction/335509

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-ChloropyrimidineHCID 74404—
ReactantHCID 178506970HCID 178506970—
Product2-(Tributylstannyl)pyrimidineHCID 2763251—

Reaction Steps

Reaction of tri-n-butylstannyl lithium with 2-chloropyrimidine affords 2-(tributylstannyl)pyrimidine which can be condensed the an acid chloride such as 5 under palladium catalysis to afford these desired ketones.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08884020B2
Source datasetuspto-grants-2014_11
ORD IDord-cbc87f6b7a6f4f01963d7ecb74fa0c08
Source noteuspto-grants-2014_11