1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid (4-pyrrolidin-1-yl-butyl)-amide

Participants

Reaction Conditions

Reaction Steps

In a flask under nitrogen, 4-Pyrrolidin-1-yl-butylamine (1.3 equiv, 10.1 g) was taken up in tetrahydrofuran (105 mL, 5 volumes). The mixture was cooled to 0° C. and 1,1′-carbonyldiimidazole (1.3 equiv, 11.6 g) was added. The mixture stirred at 0° C. for 20 minutes, then warmed to 20° C. over 10 minutes and held at 20° C. for 30 minutes.

Provenance & Evidence