HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Amino-2-naphthalenol → 8-(1-Phenethyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)naphthalen-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Amino-2-naphthalenol | HCID 8358 | — |
| Reactant | 2-Chloro-1-phenethyl-5-(trifluoromethyl)-1H-benzo[d]imidazole | HCID 69200704 | — |
| Product | 8-(1-Phenethyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-ylamino)naphthalen-2-ol | HCID 11626508 | — |
Reaction Steps
The reaction of 2-chloro-1-phenethyl-5-(trifluoromethyl)-1H-benzo[d]imidazole from step (b) above (98 mg, 0.3 mol) with 8-amino-naphthalen-2-ol (64 mg, 0.2 mmol, Aldrich) under the condition of Example 21(b) afforded the title compound. MS (ESI, pos. ion) m/z: 448(M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429608B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-fe9eb6c536f14fcf872702c51c7dd0ca |
| Source note | uspto-grants-2008_09 |