8-Amino-1,2,3,4-tetrahydronaphthalen-2-ol → HCID 178515613, compound

HRID 33556Notes

Reaction equation

HRID 33556 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7](Cl)=[N:8][C:4]=2[CH:3]=1.[NH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]2>>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[NH:6][C:7]([NH:12][C:13]3[CH:14]=[CH:15][CH:16]=[C:17]4[C:22]=3[CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]4)=[N:8][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 230669958-Amino-1,2,3,4-tetrahydronaphthalen-2-olHCID 178478307HCID 178478307, compound

Product 1

HCID 178515613HCID 178515613, compound

Procedure

The reaction of 5-bromo-2-chloro-1H-benzo[d]imidazole (345 mg, 1.5 mol, prepared according to the procedure described in WO 2004/035549 A1) with 8-amino-1,2,3,4-tetrahydronaphthalen-2-ol (163 mg, 1.0 mmol, prepared according to the procedure described in WO 2003/095420 A1) under the condition of Example 21(b) afforded the title compound. MS (ESI, pos. ion) m/z: 358 (M+1).

Workup

  1. customprepared
  2. customprepared

Sources & evidence

ORD record
ord-781fefc98175480aa98039dbbddd858a
Source dataset
uspto-grants-2008_09
Patent number
US07429608B2

Reaction notes

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