HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butyl vinyl ether → 1-Benzo[b]thiophen-4-yl-2-bromo-ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butyl vinyl ether | HCID 8108 | — |
| Reactant | 4-Bromobenzo[b]thiophene | HCID 12094208 | — |
| Reactant | 1-(Benzo[b]thiophen-4-yl)ethanone | HCID 22474126 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-Benzo[b]thiophen-4-yl-2-bromo-ethanone | HCID 57455311 | — |
Reaction Steps
1-benzo[b]thiophen-4-yl-2-bromo-ethanone was synthesised from 1-benzo[b]thiophen-4-yl-ethanone (available by the palladium coupling of 4-bromobenzo[b]thiophene with 1-vinyloxy-butane) according to the method in Example 10A(a) (6.8 g, 92%) as an orange oil; 1H NMR (CDCl3): 4.6 (2H, s), 7.4 (1H, t, J=7.8 Hz), 7.65 (1H, d, J=5.7 Hz), 7.95 (1H, dd, J=7.8, 0.9 Hz), 8.1 (1H, dt, J=7.8, 0.9 Hz), 8.3 (1H, dd, J=5.7, 0.9 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429607B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-c15c5fe751c94059b248fab455fb969d |
| Source note | uspto-grants-2008_09 |