1-(2-Methoxynaphthalen-1-yl)-2-oxopropyl acetate → 1-Hydroxy-1-(2-methoxy-naphthalen-1-yl)-propan-2-one

Participants

Reaction Steps

2-hydroxy-1-(2-methoxy-naphthalen-1-yl)-propan-1-one and 1-hydroxy-1-(2-methoxy-naphthalen-1-yl)-propan-2-one (4.5:1 mixture) (580 mg, 59%) were prepared from acetic acid 1-(2-methoxy-naphthalen-1-yl)-2-oxo-propyl ester and acetic acid 2-(2-methoxy-naphthalen-1-yl)-1-methyl-2-oxo-ethyl ester (3:1 mixture) according to the method in Example 16A(c) as an orange solid, 1H NMR (CDCl3): 1.3 (3H, d, J=7.2 Hz), 2.0 (3H, s), 3.75 (1H, d, J=5.0 Hz), 3.9 (3H, s), 3.95 (3H, s), 4.2 (1H, d, J=3.5 Hz), 5.0 (1H, m), 5.9 (1H, d, J=3.5 Hz), 7.25-7.30 (2H, m), 7.35-7.40 (2H, m), 7.45-7.50 (2H, m), 7.6 (1H, d, J=7.7 Hz), 7.75 (2H, m), 7.85 (1H, d, J=9.0 Hz), 7.90-7.95 (2H, m).

Provenance & Evidence