HCID 67383411, compound → HCID 67383429, compound

HRID 335882Notes

Reaction equation

HRID 335882 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:15]([CH3:17])(O)[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([I:18])[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:15](=[CH2:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([I:18])[CH:13]=3)[O:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 1

HCID 67383411HCID 67383411, compound

Product 1

HCID 67383429HCID 67383429, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
55 °C

Procedure

3-bromo-7-iodo-5-methyl-5H-chromeno[2,3-b]pyridin-5-ol (12.09 g, 28.9 mmol) was taken up in CH2Cl2 (116 mL) and ppts (0.100 g, 0.578 mmol) was added. The reaction was heated to 55° C. and stirred for two hours. The reaction was concentrated to afford crude 3-bromo-7-iodo-5-methylene-5H-chromeno[2,3-b]pyridine as an orange solid. The material was used immediately in the next step.

Workup

  1. additionwas added
  2. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-695506a1b9a3405982d1a6bb1ca00441
Source dataset
uspto-grants-2014_11
Patent number
US08883782B2

Reaction notes

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