HCID 53464944, compound → HCID 53464882, compound

Participants

Reaction Steps

A suspension of (S)-3-(3,6-dihydro-2H-pyran-4-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (60 mg, 0.134 mmol; prepared as described in Method BB33) and 10% Pd/C (60 mg) was stirred at rt under 1 atm of H2 gas for 12 hours. The suspension was filtered through a pad of silica gel washing with a 1:1 mixture of CH2Cl2/MeOH. The filtrate was evaporated to dryness and purified by silica gel chromatography (EtOAc to EtOAc/MeOH=100:5 to 100:7) to provide (S)-1-fluoro-7-(2-fluoropyridin-3-yl)-3-(tetrahydro-2H-pyran-4-yl)-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine as an off-white solid.

Provenance & Evidence