Dichloromethane → HCID 67383174, compound

Participants

Reaction Steps

To a solution of (S)-1-(2-amino-5′-fluoro-2′-methoxy-5H-spiro[oxazole-4,9′-xanthene]-7′-yl)pyrrolidin-2-one (377 mg, 0.98 mmol) in DCM (6 mL) boron tribromide (0.2 mL, 2.46 mmol) was added at 0° C. The bath was removed and the mixture was allowed to warm up to RT and stirred for 30 min. The reaction was quenched with sat NaHCO3 and diluted with DCM. The insoluble material was dissolved by adding MeOH. Organic layer was filtered through celite and concentrated to afford (S)-1-(2-amino-5′-fluoro-2′-hydroxy-5H-spiro[oxazole-4,9′-xanthene]-7′-yl)pyrrolidin-2-one.

Provenance & Evidence