(2-Fluoro-4-methylpyridin-3-yl)boronic acid → (S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-(2-fluoro-4-methylpyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine

Participants

Reaction Steps

The titled compound was synthesized by steps analogous to those described in method AA1 above, but using (S)-7-bromo-3-chloro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared as described in Method BB41), 2-fluoro-4-methylpyridin-3-ylboronic acid and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Provenance & Evidence