2-Methylpyridine-5-boronic acid → (S)-3-(2-amino-4'-fluoro-2'-(6-methylpyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthene]-7'-yloxy)-2,2-dimethylpropanenitrile

Participants

Reaction Steps

The titled compound was synthesized by steps analogous to those described in method AA13 above, but using (S)-2-amino-2′-bromo-4′-fluoro-5H-spiro[oxazole-4,9′-xanthen]-7′-ol (prepared as described in Method BB40 but using 4-bromo-2-fluorophenol and 2-bromo-5-methoxybenzoic acid), 2-cyano-2-methylpropyl 4-methylbenzenesulfonate, and (6-methylpyridin-3-yl)boronic acid.

Provenance & Evidence