2-(Tributylstannyl)pyrazine → (S)-2'-(3,6-dihydro-2H-pyran-4-yl)-4'-fluoro-7'-(pyrazin-2-yl)-5H-spiro[oxazole-4,9'-xanthen]-2-amine

Participants

Reaction Steps

The titled compound was synthesized by steps analogous to those described in method AA22 above, but using (S)-2-amino-2′-bromo-4′-fluoro-5H-spiro[oxazole-4,9′-xanthen]-7′-ol (prepared as described in Method BB40 but using 4-bromo-2-fluorophenol and 2-bromo-5-methoxybenzoic acid), 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and 2-(tributylstannyl)pyrazine

Provenance & Evidence