3-Pyridinylboronic acid → HCID 53464571, compound

HRID 336000Notes

Reaction equation

HRID 336000 reaction equation
Cl[C:2]1[N:7]=[C:6]([F:8])[C:5]2[O:9][C:10]3[C:15]([C@@:16]4([CH2:20][O:19][C:18]([NH2:21])=[N:17]4)[C:4]=2[CH:3]=1)=[CH:14][C:13]([C:22]1[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=1)=[CH:12][CH:11]=3.F[C:30]1[C:35](B(O)O)=[CH:34][CH:33]=[CH:32][N:31]=1.N1C=CC=C(B(O)O)C=1>>[F:8][C:6]1[C:5]2[O:9][C:10]3[C:15]([C@@:16]4([CH2:20][O:19][C:18]([NH2:21])=[N:17]4)[C:4]=2[CH:3]=[C:2]([C:35]2[CH:30]=[N:31][CH:32]=[CH:33][CH:34]=2)[N:7]=1)=[CH:14][C:13]([C:22]1[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=1)=[CH:12][CH:11]=3

Participants

4

Reactant 3

HCID 27343783-Pyridinylboronic acidHCID 27832702-Fluoropyridine-3-boronic acidHCID 86658487HCID 86658487, compound

Product 1

HCID 53464571HCID 53464571, compound

Procedure

The titled compound was synthesized by steps analogous to those described in method AA1 above, but using (S)-3-chloro-1-fluoro-7-(2-fluoropyridin-3-yl)-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared as described as in Method BB33), 2-fluoropyridin-3-ylboronic acid and 3-pyridylboronic acid

Sources & evidence

ORD record
ord-b8b32db0719e4c1bb81d58b83dc16fe6
Source dataset
uspto-grants-2014_11
Patent number
US08883782B2

Reaction notes

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