HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4,4-Difluoropiperidine hydrochloride → (S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4,4-Difluoropiperidine hydrochloride | HCID 2758351 | — |
| Edukt | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Edukt | (S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine | HCID 58466258 | — |
| Produkt | (S)-3-(3,3-difluoropyrrolidin-1-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5'-H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine | HCID 53464257 | — |
Reaktionsschritte
The title compound was synthesized by steps analogous to those described in method CC4 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared by steps analogous to those described in Method BB33), 2-fluoropyridin-3-ylboronic acid and 4,4-difluoropiperidine hydrochloride.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08883782B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-2a26bb09207e445caf53603825a365eb |
| Quellennotiz | uspto-grants-2014_11 |