Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Iodophenol → (S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Iodophenol | HCID 10894 | — |
| 반응물 | 3,6-Dihydro-2H-pyran-4-boronic acid pinacol ester | HCID 11218053 | — |
| 반응물 | 5-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride) | HCID 57416482 | — |
| 반응물 | (S)-3-bromo-7-iodo-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine | HCID 58466209 | — |
| 생성물 | (S)-3-(3,6-dihydro-2H-pyran-4-yl)-7-(5-(prop-1-ynyl)pyridin-3-yl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine | HCID 53464259 | — |
반응 단계
The titled compound was synthesized by steps analogous to those described in method AA1 above, but using (S)-3-bromo-7-iodo-5′H-spiro[chromeno[2,3-b]pyridine-5,4′-oxazol]-2′-amine (prepared using the same procedures as described in Method CC6 but using 4-iodophenol), 5-(prop-1-ynyl)pyridin-3-ylboronic acid, and 2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883782B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-d62f79dac86d4a3898d4d509a4dcb22b |
| 출처 메모 | uspto-grants-2014_11 |