HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → (S)-4'-fluoro-2'-(1-methyl-1H-pyrazol-4-yl)-7'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthen]-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole | HCID 2773987 | — |
| Edukt | 5-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride) | HCID 57416482 | — |
| Edukt | (S)-2-amino-7'-bromo-4'-fluoro-5H-spiro[oxazole-4,9'-xanthen]-2'-ol | HCID 58466133 | — |
| Produkt | (S)-4'-fluoro-2'-(1-methyl-1H-pyrazol-4-yl)-7'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthen]-2-amine | HCID 53464260 | — |
Reaktionsschritte
The titled compound was synthesized by steps analogous to those described in method AA8 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[oxazole-4,9′-xanthen]-2′-ol (prepared by steps analogous to those described in Method BB40 and Example 2), 5-(prop-1-ynyl)pyridin-3-ylboronic acid, and 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08883782B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-a3ec72862790418c81f6994b8f9d4868 |
| Quellennotiz | uspto-grants-2014_11 |