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HRID 336008作成日：2026年10月25日

2-Methyl-3-butyn-2-ol → (S)-4-(2-amino-5'-fluoro-2'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthene]-7'-yl)-2-methylbut-3-yn-2-ol

https://huagongshe.com/reaction/336008

反応式

関与物質

役割名称HCID仕込み量
反応物2-Methyl-3-butyn-2-olHCID 8258—
反応物5-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride)HCID 57416482—
反応物(S)-2-amino-7'-bromo-4'-fluoro-5H-spiro[oxazole-4,9'-xanthen]-2'-olHCID 58466133—
生成物(S)-4-(2-amino-5'-fluoro-2'-(5-(prop-1-ynyl)pyridin-3-yl)-5H-spiro[oxazole-4,9'-xanthene]-7'-yl)-2-methylbut-3-yn-2-olHCID 58466192—

反応手順

The titled compound was synthesized by steps analogous to those described in method AA21 above, but using (S)-2-amino-7′-bromo-4′-fluoro-5H-spiro[oxazole-4,9′-xanthen]-2′-ol (prepared by steps analogous to those described in Method BB40 and Example 2), 5-(prop-1-ynyl)pyridin-3-ylboronic acid, and 2-methylbut-3-yn-2-ol.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08883782B2
出典データセットuspto-grants-2014_11
ORD IDord-7832025272b64c15b6adc6f7e71e2af2
出典メモuspto-grants-2014_11