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3-Pyridinylboronic acid → (S)-1-fluoro-7-(5-(prop-1-ynyl)pyridin-3-yl)-3-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Pyridinylboronic acid | HCID 2734378 | — |
| 反応物 | 5-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride) | HCID 57416482 | — |
| 反応物 | (S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine | HCID 58466258 | — |
| 生成物 | (S)-1-fluoro-7-(5-(prop-1-ynyl)pyridin-3-yl)-3-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine | HCID 58466193 | — |
反応手順
The titled compound was synthesized by steps analogous to those described in method A1 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared as described in Method BB33), pyridin-3-ylboronic acid and 5-(prop-1-ynyl)pyridin-3-ylboronic acid
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08883782B2 |
| 出典データセット | uspto-grants-2014_11 |
| ORD ID | ord-907b1d7cb5994c73b9ce94ac0d205141 |
| 出典メモ | uspto-grants-2014_11 |