Morpholine → HCID 53465213, compound

HRID 336013Notes

Reaction equation

HRID 336013 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:19][O:18][C:17]([NH2:20])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[C:10]([F:22])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[C:23]([C:25]1[CH:26]=[C:27](B(O)O)[CH:28]=[CH:29][CH:30]=1)#[N:24].[NH:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1>>[NH2:20][C:17]1[O:18][CH2:19][C@:15]2([C:14]3[CH:13]=[C:12]([N:34]4[CH2:39][CH2:38][O:37][CH2:36][CH2:35]4)[N:11]=[C:10]([F:22])[C:9]=3[O:8][C:5]3[C:4]2=[CH:3][C:2]([C:29]2[CH:30]=[C:25]([CH:26]=[CH:27][CH:28]=2)[C:23]#[N:24])=[CH:7][CH:6]=3)[N:16]=1

Participants

4

Reactant 3

HCID 8083MorpholineHCID 27343253-Cyanophenylboronic acidHCID 58466258(S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine

Product 1

HCID 53465213HCID 53465213, compound

Procedure

The titled compound was synthesized by steps analogous to those described in Method CC4 above using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′ oxazol]-2′-amine (prepared as described in Method BB33), 3-cyanophenylboronic acid and morpholine.

Sources & evidence

ORD record
ord-ffdf34600e40448da3514175e852c8de
Source dataset
uspto-grants-2014_11
Patent number
US08883782B2

Reaction notes

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