HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → (S)-7-(2-fluoropyridin-3-yl)-3-morpholino-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-thiazol]-2'-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-Fluoropyridine-3-boronic acid | HCID 2783270 | — |
| Reactant | (S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-thiazol]-2'-amine | HCID 86658508 | — |
| Product | (S)-7-(2-fluoropyridin-3-yl)-3-morpholino-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-thiazol]-2'-amine | HCID 53464319 | — |
Reaction Steps
The titled compound was synthesized by steps analogous to those described in Method CC10 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-thiazol]-2′-amine (prepared as described in Method BB26 but using 7-bromo-3-chloro-5H-chromeno[2,3-c]pyridin-5-one), 2-fluoropyridin-3-ylboronic acid and morpholine. MS m/z=450.1 [M+H]+. Calculated for C23H20FN5O2S: 449.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08883782B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-c20e827f09fa4005856a26f04188dbb7 |
| Source note | uspto-grants-2014_11 |